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| Vieira,Juliana; Matsuzaki,Patricia; Nagamine,Márcia Kazumi; Haraguchi,Mitsue; Akisue,Gokithi; Gorniak,Silvana Lima; Dagli,Maria Lúcia Zaidan. |
| This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then, Swiss male mice received, by intraperitoneal injection, once a day, 12.5; 25 or 50mg/Kg of P. paniculata BR for seven days. This protocol started in the same day of tumor inoculation with 5X10(6) cells i.p. The treatment with butanolic residue of P.paniculata i.p caused a significant increase in the ascitic volume; however, a significant decrease in tumor cells... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pfaffia paniculata; Ehrlich; Intraperitoneal treatment. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000300014 |
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| Dipe,Vânius Vinícius; Gotardo,André Tadeu; Haraguchi,Mitsue; Górniak,Silvana Lima. |
| The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leucaena leucocephala; Mimosine; Ehrlich tumor; Cyclophosphamide; Anticancer activity. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010 |
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| Hansen,Daiane; Haraguchi,Mitsue; Alonso,Antonio. |
| The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sucupira; Pterodon/phytochemistry; Pterodon/pharmacognosy; Diterpenes/biological activity; Isoflavones/biological activity; Medicinal plants. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400002 |
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| Brum,Karine Bonucielli; Haraguchi,Mitsue; Garutti,Mirella Biasoli; Nóbrega,Fernanda Nogarol; Rosa,Beneval; Fioravanti,Maria Clorinda Soares. |
| Brachiaria species contain steroidal saponins and are involved in outbreaks of hepatogenous photosensitization. This research presents the levels of a steroidal saponin, protodioscin, in the seeds and aerial parts of B. brizantha and B. decumbens during different developmental stages (growth, bloom, fructification and seed fall). The butanolic fraction of the ethanolic extract of each stage was submitted to thin layer chromatography (TLC) and spectrophotometric analysis through the Ehrlich reagent in 515nm. The chromatograms in TLC of the butanolic fraction of B. brizantha and B. decumbens showed similar spots as the protodioscin standard. The estimated level of protodioscin isomers in B. brizantha and B. decumbens ranged from 0.5% to 2.1%, having the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brachiaria spp.; Photosensitization; Protodioscin; Spectrophotometry; Steroidal saponins. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000100049 |
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